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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#_4 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#_3 http://www.w3.org/ns/prov#value Adhesion of HT-29 cells on a monolayer of HUVEC pretreated with TNFα was dependent on E-selectin expression but was independent of SAPK2/p38 activity of both HUVEC and tumor cells. The adhesion of HT-29 cells to E-selectin-expressing HUVEC led to the activation of SAPK2/p38 in the tumor cells as reflected by the increased phosphorylation of the actin-polymerizing factor HSP27 by mitogen-activated protein kinase 2/3, a direct target of SAPK2/p38. Moreover, a recombinant E-selectin/Fc chimera quickly increased the activation of SAPK2/p38 in HT-29 cells. Blocking the increased activity of SAPK2/p38 of HT-29 cells by SB203580 or by expressing a dominant negative form of SAPK2/p38 inhibited their transendothelial migration. http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11448946 http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#_4 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11448946 http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#_3 http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o http://purl.org/dc/terms/created 2014-07-03T14:29:33.308+02:00 http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAmK4fjEhJjT-frM8HP684Acc4pg1sCo1YoHGkzqcG8o http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234