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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#_8 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#_7 http://www.w3.org/ns/prov#value Preformed Mac-1 is stored in granules in neutrophils and can be rapidly mobilized to the neutrophil surface after exposure to degranulation stimuli such as the bacterial peptide fMLP or to cytokines (Altieri and Edgington, 1988). However, it is not yet competent for ligand binding. The ligand binding site lies on an extracellular region of the α subunit called the I domain, that is inaccessible to potential ligands unless integrins are activated. Integrin activation involves a conformational change such that the I domain is exposed (Oxvig et al., 1999). This change may be induced by phosphorylation of the cytoplasmic tail of the β subunit (Buyon et al., 1997), possibly through a pathway involving the small GTP-binding protein Rho, but this is still unclear. http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12891700 http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#_8 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12891700 http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#_7 http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ http://purl.org/dc/terms/created 2014-07-03T14:29:34.934+02:00 http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAB0gR4bMVmq5A3XYgJ6sQlU_mJrjQ1OhrV_-BPIHh5NQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234