@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAC2_a2ORD78JOl1t3zSYWxbljUd2iJAgtZoCqqG-q9_E> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAC2_a2ORD78JOl1t3zSYWxbljUd2iJAgtZoCqqG-q9_E#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 geneProductOf: sfam:VEGF%20Family ;
    a Protein: .
  sub:_2 belv:variantOf hgnc:6307 ;
    a proteinModification: , psimod:00696 .
  sub:_3 occursIn: obo:CL_0000115 , species:9606 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(SFAM:\"VEGF Family\") => p(HGNC:KDR,pmod(P,Y,1059))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value """The mitogenic and chemotactic effects of VEGF in ECs are mediated mainly through VEGFR2
(76). VEGFR2 is activated through ligandstimulated receptor dimerization
and transphosphorylation (autophosphorylation) of tyrosine residues in the cytoplasmic
kinase domain. At present, tyrosine residues 951 and 996 in the kinase insert
domain, and 1054 and 1059 in the kinase catalytic domain, have been identified
as autophosphorylation sites for VEGFR2 in a bacterial expression system (30).
This event is followed by activation of downstream signaling pathways such as
Src, PI3 kinase, MAP kinases, and Akt, which is essential for VEGF-induced actin
reorganization, cell migration, and proliferation of ECs.""" ;
    prov:wasQuotedFrom pubmed:17511588 .
  sub:_5 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:17511588 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:31:17.851+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}