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p(MGI:Hnf1a) -> r(MGI:Mttp)
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Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 19
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Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 19
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Mttp transfers lipid to APOB during translocation of the protein into the ER lumen to form partially lipidated APOB these small particles then fuse with a triacylglycerol droplet in the ER lumen to produce VLDLs the promoter region of the Mttp gene contains elements predicted to bind transcription factors, HNF-1, HNF-4 and AP-1, that might dictate the cell type-specific expression of Mttp hepatic Mttp mRNA levels are increased in hampsters fed a high-fat diet
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