@prefix this: <http://www.tkuhn.ch/bel2nanopub/RADV4VzG_2soAIhYixWjSKWLHBVNX26avl0xtJnNTNQ6E> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RADV4VzG_2soAIhYixWjSKWLHBVNX26avl0xtJnNTNQ6E#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 hasAgent: sub:_2 ;
    a go:0016301 .
  sub:_2 geneProductOf: sfam:AKT%20Family ;
    a Protein: .
  sub:_3 occursIn: obo:CLO_0001230 , species:9606 ;
    hasAnnotation: sub:_4 ;
    rdf:object sub:_1 ;
    rdf:predicate belv:increases ;
    rdf:subject schem:Ionomycin ;
    a rdf:Statement .
  sub:_4 dct:subject "TextLocation" ;
    rdf:value "Abstract" .
  sub:assertion rdfs:label "a(SCHEM:Ionomycin) -> kin(p(SFAM:\"AKT Family\"))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value """However, IL-1β-induced NF-κB activity is attenuated by increased intracellular calcium
in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc
and/or Akt. Ionomycin and CaMKKc overexpression increases Akt phosphorylation
on Thr308 and enzyme activity. Under these conditions or upon overexpression of
wild type Akt, IL-1β-induced IKKβ activity is diminished. Furthermore, a dominant
negative mutant of Akt abolishes IKKβ inhibition by CaMKKc and ionomycin, suggesting
that Akt acts as a mediator of CaMKK signaling to inhibit IL-1β-induced
IKK activity at an upstream target site.""" ;
    prov:wasQuotedFrom pubmed:11976320 .
  sub:_6 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11976320 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:31:17.165+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}