. . . . . . . . . . . . . . . . "TextLocation" . "Results" . "p(HGNC:VEGFA) -> kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\"))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "20131211" . "VEGF induced tyrosine phosphorylation of the regulatory p85 subunit of PI 3-kinase,\nevidenced by immunoblotting of anti-p85 immunoprecipitates with an anti-pY mAb\n(Fig. 5b). Moreover, immunoblotting of anti-pY immunoprecipitates with specific\np85 mAb showed an increased association of p85 with tyrosine-phosphorylated proteins,\nwhich was maximal after 5 min of VEGF treatment (Fig. 5c). To determine\nwhether VEGF-induced p85 phosphorylation regulates p110, the catalytic counterpart\nof PI 3-kinase, we performed in vitrokinase assays using PI 4,5-bisphosphate\nas a substrate. As shown in Fig. 5d, VEGF induced peak activation (6-fold) of PI\n3-kinase activity at 5 min." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:31:16.313+02:00"^^ . . .