[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6204" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_2", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://semanticscience.org/resource/SIO_000255" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_3" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://purl.bioontology.org/ontology/MSH/D002294" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_3", "http://purl.org/dc/terms/subject" : [ { "@value" : "TextLocation" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#value" : [ { "@value" : "Results" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "p(HGNC:JUN) -> path(MESHD:\"Carcinoma, Squamous Cell\")" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 2000 hand curated statements drawn from 57 PubMeds." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All Rights Reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Small Corpus Document" } ], "http://purl.org/dc/terms/license" : [ { "@value" : "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "1.6" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "We next asked whether components of the JNK cascade could directly promote human epidermal\nneoplasia. We expressed either active MKK7 or c-Jun in primary keratinocytes\nand examined their capacity to promote tumorigenesis in combination with\nRas in the absence of IκBα. First, we confirmed induction of AP1-dependent gene\nreporter activity by MKK7 in vitro (Supplementary Fig. S4). Surface skin grafts\nwere then regenerated with primary keratinocytes expressing MKK7 and Ras; these\ndeveloped into clinical tumors resembling SCC (Fig. 3A). Dermal invasion, one of\nthe hallmarks of spontaneous human SCC, is apparent in tumors induced by MKK7 and\nRas as revealed by both histologic appearance and BMZ disruption (Fig. 3B–C).\nMKK7 and Ras-induced neoplasia depends on intact AP1 function as concurrent expression\nof DNc-Jun prevents tumorigenesis (Fig. 3A–C)." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/17440097" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_5", "http://www.w3.org/2000/01/rdf-schema#comment" : [ { "@value" : "support@belframework.org" } ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/17440097" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:29:32.896+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAFhTriG4ozZ0Cmd0UVZMJ7pb_poBpOWLpem4N9oJcZTw#pubinfo" } ]