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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#_7 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#_6 http://www.w3.org/ns/prov#value PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation of GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin and IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells, respectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated by pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast, the effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines were not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig. 2A), excluding the possibility that PKA induces GSK-3 phosphorylation through activation of PI3K. http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11035810 http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#_7 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11035810 http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#_6 http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw http://purl.org/dc/terms/created 2014-07-03T14:29:34.684+02:00 http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAGFLEkqMvLS74xaq1mlLEMEvz-TG33KKoBWPcVMlBiqw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234