. . . . . . . . . . . . . . . . "TextLocation" . "Abstract" . "p(HGNC:LRIG1) -> p(HGNC:EGFR,pmod(U,K))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Here we tested whether the related human LRIG1 (also called Lig-1) protein can act\nas a negative regulator of EGF receptor and its relatives, ErbB2, ErbB3, and ErbB4.\nWe observed that in co-transfected 293T cells, LRIG1 forms a complex with\neach of the ErbB receptors independent of growth factor binding. We further observed\nthat co-expression of LRIG1 with EGF receptor suppresses cellular receptor\nlevels, shortens receptor half-life, and enhances ligand-stimulated receptor ubiquitination." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:34.113+02:00"^^ . . .