@prefix dc: . @prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix Protein: . @prefix hgnc: . @prefix geneProductOf: . @prefix mesh: . @prefix occursIn: . @prefix hasAnnotation: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 geneProductOf: hgnc:12687; a Protein: . sub:_2 belv:degradationOf sub:_3 . sub:_3 geneProductOf: hgnc:4910; a Protein: . sub:_4 occursIn: mesh:D001769, mesh:D002478; hasAnnotation: sub:_5; rdf:object sub:_2; rdf:predicate belv:directlyIncreases; rdf:subject sub:_1; a rdf:Statement . sub:_5 dc:subject "TextLocation"; rdf:value "Review" . sub:assertion rdfs:label "p(HGNC:VHL) => deg(p(HGNC:HIF1A))" . } sub:provenance { beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds."; dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved."; dce:title "BEL Framework Small Corpus Document"; dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License"; pav:authoredBy sub:_7; pav:version "1.6" . sub:_6 prov:value """Hydroxylation at two prolyl residues (Pro402 and Pro564 in human HIF-1α) mediates interactions with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex that targets HIF-α for proteasomal destruction28, 29, 30, 34. Each site can interact independently with VHL E3, potentially contributing to the extremely rapid proteolysis of HIF-α that is observed in oxygenated cells34. These sites contain a conserved LxxLAP motif and are targeted by a newly defined prolyl hydroxylase activity, that in mammalian cells is provided by three isoforms termed PHD (prolyl hydroxylase domain) 1-3 (refs. 31,32)."""; prov:wasQuotedFrom pubmed:12778166 . sub:_7 rdfs:comment "support@belframework.org"; rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:12778166; prov:wasDerivedFrom beldoc:, sub:_6 . } sub:pubinfo { this: dc:created "2014-07-03T14:29:32.242+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }