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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#_6 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#_5 http://www.w3.org/ns/prov#value Here we tested whether the related human LRIG1 (also called Lig-1) protein can act as a negative regulator of EGF receptor and its relatives, ErbB2, ErbB3, and ErbB4. We observed that in co-transfected 293T cells, LRIG1 forms a complex with each of the ErbB receptors independent of growth factor binding. We further observed that co-expression of LRIG1 with EGF receptor suppresses cellular receptor levels, shortens receptor half-life, and enhances ligand-stimulated receptor ubiquitination. http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15345710 http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#_6 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15345710 http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#_5 http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q http://purl.org/dc/terms/created 2014-07-03T14:29:34.105+02:00 http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAJO12Nbni_2VtQedeJA9mMzZG4Ku9wCl-GiA303QLt0Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234