sub:provenance {
beldoc: dce:description "Approximately 61,000 statements." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title "BEL Framework Large Corpus Document" ;
pav:authoredBy sub:_6 ;
pav:version "1.4" .
sub:_4 dce:identifier "Landes Bioscience - Autocrine VEGF Signaling in Breast Cancer" ;
dce:title "Landes Bioscience - Autocrine VEGF Signaling in Breast Cancer" ;
dce:type "Other" .
sub:_5 prov:value "VEGFR-1 and VEGFR-2 mRNA was identified in a number of breast cancer cell lines including T-47D, MCF7, MDA-MB-453, and MDA-MB-231, and these cancer cells were shown to respond to VEGF.85,86 VEGF stimulation increased the invasiveness of T-47D cells in the presence of fibronectin.85 ERK-1 and -2 were activated in response to VEGF in T-47D cells; PI3-K and its downstream target Akt were also activated. Since T-47D cells secrete VEGF87 it is likely that an autocrine VEGF loop exists within these cells. PI3-K activation has often been implicated in cellular invasion88 and may be the signalling mechanism in T-47D cells that mediates VEGF-induced cell invasion." ;
prov:wasQuotedFrom sub:_4 .
sub:_6 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource sub:_4 ;
prov:wasDerivedFrom beldoc: ,
sub:_5 .
}