@prefix this: <http://www.tkuhn.ch/bel2nanopub/RALFr4k_7Lh74IqKelOD1kOKP_6bENGQ7sg0tFaVz5WCM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RALFr4k_7Lh74IqKelOD1kOKP_6bENGQ7sg0tFaVz5WCM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 geneProductOf: hgnc:17360 ;
    a Protein: .
  sub:_2 belv:variantOf hgnc:3236 ;
    a proteinModification: , psimod:01148 .
  sub:_3 occursIn: mesh:D001921 , atcc:CRL-11268.aspx , species:9606 ;
    hasAnnotation: sub:_4 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:_4 dct:subject "TextLocation" ;
    rdf:value "Results" .
  sub:assertion rdfs:label "p(HGNC:LRIG1) -> p(HGNC:EGFR,pmod(U,K))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.6" .
  sub:_5 prov:value """To determine whether LRIG1 expression influences the ubiquitination and degradation
rate of ErbB receptors in the inducible expression system, we focused on the
effect of LRIG1 expression on the properties of EGFR in the PC3-LRIG1 cells. Similar
to the results with transfected 293T cells (Fig. 3), we observed that the induction
of LRIG1 expression markedly augmented the ubiquitination of EGFR in response
to EGF treatment (Fig. 5A). This potentiation of ligand-stimulated EGFR ubiquitination
correlated with a suppression of EGFR tyrosine phosphorylation and
receptor levels after growth factor treatment.""" ;
    prov:wasQuotedFrom pubmed:15345710 .
  sub:_6 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15345710 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:29:34.145+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}