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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_4 http://purl.org/dc/elements/1.1/identifier Entrez Gene GeneRifs summary PRKCN Human http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_4 http://purl.org/dc/elements/1.1/title Entrez Gene GeneRifs summary PRKCN Human http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_4 http://purl.org/dc/elements/1.1/type Online Resource http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_5 http://www.w3.org/ns/prov#value OMIM summary: Human: PRKCN belongs to a protein kinase C subfamily of serine/threonine kinases characterized by a large molecular mass and the presence of a pleckstrin homology domain. Entrez Gene GeneRifs summary: Human: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_4 http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_4 http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#_5 http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg http://purl.org/dc/terms/created 2014-07-03T14:29:44.841+02:00 http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAP4pUlWQjl5Xe-nfxqZ2HyMvYWUVaARgKhVjgoqDwHDg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234