. . . . . . . . . . . . "TextLocation" . "Review" . "a(CHEBI:FAD) -> bp(GO:\"pyruvate oxidation\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Classically, it is considered that the number of normal mtDNA copies must fall below\n20–40% of basal levels to induce mitochondrial dysfunction and adverse events\n[6]. Below this threshold, hepatic mtDNA depletion can impair the MRC. This impairment\ncan hamper the regeneration of NAD+ and FAD, thus leading to a secondary\ninhibition of the oxidation of fatty acids and pyruvate." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:31.011+02:00"^^ . . .