. . . . . . . . . . . . . . . . "p(HGNC:VEGFA) -> kin(p(PFH:\"AKT Family\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Landes Bioscience - Autocrine VEGF Signaling in Breast Cancer" . "Landes Bioscience - Autocrine VEGF Signaling in Breast Cancer" . "Other" . "VEGFR-1 and VEGFR-2 mRNA was identified in a number of breast cancer cell lines including T-47D, MCF7, MDA-MB-453, and MDA-MB-231, and these cancer cells were shown to respond to VEGF.85,86 VEGF stimulation increased the invasiveness of T-47D cells in the presence of fibronectin.85 ERK-1 and -2 were activated in response to VEGF in T-47D cells; PI3-K and its downstream target Akt were also activated. Since T-47D cells secrete VEGF87 it is likely that an autocrine VEGF loop exists within these cells. PI3-K activation has often been implicated in cellular invasion88 and may be the signalling mechanism in T-47D cells that mediates VEGF-induced cell invasion." . . "Selventa" . . . . "2014-07-03T14:29:44.397+02:00"^^ . . .