@prefix this: <http://www.tkuhn.ch/bel2nanopub/RARZWt_fObQQyWBk_GqB26QpDMA_mj458_DB89jWJR7s0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RARZWt_fObQQyWBk_GqB26QpDMA_mj458_DB89jWJR7s0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix pfh: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: pfh:E2F%20Family;
    a Protein: .
  
  sub:_2 geneProductOf: hgnc:7329;
    a RNA: .
  
  sub:_3 occursIn: species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(PFH:\"E2F Family\") -> r(HGNC:MSH6)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "1.4" .
  
  sub:_4 dce:identifier "Weizmann Institute open day 2002: cancer research and therapy";
    dce:title "Weizmann Institute open day 2002: cancer research and therapy";
    dce:type "Other" .
  
  sub:_5 prov:value "Other novel E2F-regulated genes, identified using the DNA microarray analysis, are involved in mitosis and DNA repair. The identification of mitotic genes, including the kinases Bub1b and cdc2, as E2F-regulated genes indicates that E2F affects cell cycle progression both at the S-phase and during mitosis. The molecular mechanism(s) of E2F-dependent regulation of mitotic genes is currently being studied. The identification of DNA repair genes, including MSH2, MSH6 and BRCA1, as E2F-regulated genes raises the possibility that E2F plays a role in the response to DNA damage. This notion is supported by recent reports demonstrating that various DNA damaging agents induce an increase in E2F-1 protein level.";
    prov:wasQuotedFrom sub:_4 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource sub:_4;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:44.235+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}