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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_4 http://purl.org/dc/elements/1.1/identifier Weizmann Institute open day 2002: cancer research and therapy http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_4 http://purl.org/dc/elements/1.1/title Weizmann Institute open day 2002: cancer research and therapy http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_4 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_5 http://www.w3.org/ns/prov#value E2F up-regulates expression of genes involved in DNA replication, DNA repair and mitosis We use DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data demonstrate that E2F up-regulates the expression of tens of genes not previously described as E2F target genes. Many of these novel E2F-regulated genes code for components of the DNA replication machinery. Among them are the genes coding for replication protein A (RPA). RPA is the most abundant ssDNA binding protein in eukaryotic cells and it plays an essential role in DNA replication. It is a heterotrimer composed of 70kDa (RPA1), 32kDa (RPA2) and 14kDa (RPA 3) subunits and our data show that expression of the genes, coding for these three subunits, is up-regulated by E2F. The regulation of the RPA2 gene was studied in greater detail and we show that it is directly regulated by E2F via E2F-binding sites in its promoter. http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_4 http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_4 http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#_5 http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk#pubinfo http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk http://purl.org/dc/terms/created 2014-07-03T14:29:44.231+02:00 http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RASuUiyN_ycydq3KSyPTNeLOlPoiHBQheEuRDsBw92tMk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234