. . . . . . . . . . . . . . . . . . . "TextLocation" . "Review" . "gtp(p(HGNC:RAP1A)) =| kin(p(HGNC:RAF1))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "20131211" . "Both B-Raf and C-Raf can bind to other small GTPases, most notably Rap1.115,131,132\n The effector domains of Rap1 and Ras are nearly identical, but activation of\nthese proteins produces vastly different downstream effects. Furthermore, Rap1\nmediates distinct effects after binding to various Raf isoforms. The B-Raf–Rap1\ncomplex activates B-Raf, whereas the C-Raf–Rap1 interaction does not activate C-Raf\nand, in fact, may be inhibitory.115,132,133 This occurs because Rap1 binds\nto the CRD of C-Raf with higher affinity than Ras and excludes Ras from binding." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:31:15.637+02:00"^^ . . .