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All Rights Reserved. http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#_7 http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#_6 http://www.w3.org/ns/prov#value Further, LPS + IFNγ -induced expression of iNOS and Nox1 was attenuated by the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor PD98059, the JNK inhibitor SP600125, the Jak2 inhibitor AG490 and the NFκB inhibitor MG132, but not by the p38 mitogen-activated protein kinase inhibitor SB203580. LPS + IFNγ stimulated phosphorylation of ERK, JNK and Jak2, and degradation of IκB, but only Jak2 phosphorylation was sensitive to tripterine (50-200 nM). Further, tripterine diminished the increased vascular permeability in inflamed air pouches. http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19508391 http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#_7 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19508391 http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#_6 http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII http://purl.org/dc/terms/created 2014-07-03T14:31:16.476+02:00 http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUpl-qBazLgXR_ObiNvH6ygj_TaFGdLx4o8rc-jtfnII http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234