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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#_7 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#_6 http://www.w3.org/ns/prov#value Co-transfection of luciferase reporter plasmids containing these sequences along with expression plasmids encoding either an activated β-catenin containing mutations in the GSK-3h phosphorylation sites (β-catenin/4145) or with a TCF3-VP16 fusion protein demonstrated that both promoter sequences could be activated by transcriptional mediators of Wnt signaling (Figs. 7A and B). Addition of both h-catenin/4154 and TCF3-VP16 resulted in cooperative activation of both promoters (Figs. 7A and B). Furthermore, a dominantnegative TCF3 construct repressed both BMP4 and N-myc promoters (Figs. 7C and D). Chromatin immunoprecipitation assays show that β-catenin associates with the conserved LEF/TCF DNA binding sites located in the BMP4 and N-myc promoters, indicating direct regulation of these promoters by canonical Wnt signaling (Figs. 7E and F). Together, these results demonstrate that BMP4 and Nmyc are targets of Wnt/β-catenin signaling in lung airway epithelium. http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15907834 http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#_7 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15907834 http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#_6 http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g#pubinfo http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g http://purl.org/dc/terms/created 2014-07-03T14:29:32.120+02:00 http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAUu8RmhzjkImMs_1C9dkvxV2R0i5LZbUSHxhudlUwZ1g http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234