@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAV3gTrtxKqrmElQdWNSmE6xdTMdN0s2BjNNKVwdQu4rg> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAV3gTrtxKqrmElQdWNSmE6xdTMdN0s2BjNNKVwdQu4rg#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0005525 .
  
  sub:_2 geneProductOf: hgnc:9855;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0016301 .
  
  sub:_4 geneProductOf: hgnc:1097;
    a Protein: .
  
  sub:_5 occursIn: mesh:D003593, species:9606;
    hasAnnotation: sub:_6;
    rdf:object sub:_3;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:_6 dc:subject "TextLocation";
    rdf:value "Review" .
  
  sub:assertion rdfs:label "gtp(p(HGNC:RAP1A)) => kin(p(HGNC:BRAF))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_8;
    pav:version "1.6" .
  
  sub:_7 prov:value """Both B-Raf and C-Raf can bind to other small GTPases, most notably Rap1.115,131,132
 The effector domains of Rap1 and Ras are nearly identical, but activation of
these proteins produces vastly different downstream effects. Furthermore, Rap1
mediates distinct effects after binding to various Raf isoforms. The B-Raf–Rap1
complex activates B-Raf, whereas the C-Raf–Rap1 interaction does not activate C-Raf
and, in fact, may be inhibitory.115,132,133  This occurs because Rap1 binds
to the CRD of C-Raf with higher affinity than Ras and excludes Ras from binding.""";
    prov:wasQuotedFrom pubmed:16170185 .
  
  sub:_8 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:16170185;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dc:created "2014-07-03T14:29:30.490+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}