. . . . . . . . . . . . . . . . . . "TextLocation" . "Review" . "p(HGNC:TRAF6) -> kin(complex(NCH:\"IkappaB Kinase Complex\"))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "It has been shown recently that ubiquitination plays an important role in TAK1 activation\n(26, 27). IKK activation by TRAF6 requires a dimeric ubiquitin-conjugating\nenzyme complex composed of Ubc13 and Uev1A as well as the TAK1·kinase complex.\nTRAF6 can interact through its RING finger domain with Ubc13 in the Ubc13·Uev1A\ncomplex. This Ubc·TRAF6 complex catalyzes the formation of a Lys-63-linked polyubiquitin\nchain, which triggers TAK1 activation through a unique proteasome-independent\nmechanism." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:33.199+02:00"^^ . . .