sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_5 ; pav:version "1.4" . sub:_3dce:identifier "Landes Bioscience - Altered Integrin Expression in Three Common Types of Human Cancer=Breast Cancer" ; dce:title "Landes Bioscience - Altered Integrin Expression in Three Common Types of Human Cancer=Breast Cancer" ; dce:type "Other" . sub:_4prov:value "Furthermore, epidermal growth factor and its receptor (EGFR), as well as the breast cancer-related protein ERBB-2, have been reported to mediate up-regulation of b1 integrin function and breast cancer progression. Activation of PI3-kinase plays a role in the signalling of both of these receptors. 74 It has also been suggested that the overexpression of breast cancer-related protein ERBB-2 may induce fibronectin-dependent invasion with concomitant down-regulation of a4 integrin cell surface expression. 75" ; prov:wasQuotedFromsub:_3 . sub:_5rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcesub:_3 ; prov:wasDerivedFrombeldoc: , sub:_4 . }