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apoa1 is likely to play the predominant role in transporting peripheral cell cholesterol through the plasma compartment to the liver apoa1 gene transcription rates are not highly regulated, compared to those of ABCA1 and other catalytic factors of the HDL cycle Sp1, a transcription factor, plays a major role in regulating apoa1 transcription rates PPARs regulate phospholipid efflux to apoa1
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