@prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dct: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix Protein: . @prefix hgnc: . @prefix geneProductOf: . @prefix go: . @prefix hasAgent: . @prefix hasAnnotation: . @prefix atcc: . @prefix occursIn: . @prefix species: . @prefix mesh: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 geneProductOf: hgnc:5464; a Protein: . sub:_2 hasAgent: sub:_3; a go:0016301 . sub:_3 geneProductOf: hgnc:4617; a Protein: . sub:_4 occursIn: mesh:D002460, mesh:D007668, atcc:CRL-2210.aspx, species:10116; hasAnnotation: sub:_5; rdf:object sub:_2; rdf:predicate belv:increases; rdf:subject sub:_1; a rdf:Statement . sub:_5 dct:subject "TextLocation"; rdf:value "Results" . sub:assertion rdfs:label "p(HGNC:IGF1) -> kin(p(HGNC:GSK3B))" . } sub:provenance { beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds."; dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved."; dce:title "BEL Framework Small Corpus Document"; dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License"; pav:authoredBy sub:_7; pav:version "1.6" . sub:_6 prov:value """PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation of GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin and IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells, respectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated by pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast, the effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines were not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig. 2A), excluding the possibility that PKA induces GSK-3 phosphorylation through activation of PI3K."""; prov:wasQuotedFrom pubmed:11035810 . sub:_7 rdfs:comment "support@belframework.org"; rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:11035810; prov:wasDerivedFrom beldoc:, sub:_6 . } sub:pubinfo { this: dct:created "2014-07-03T14:29:34.680+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }