@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAaIrcb1ffIOk3ecA9-3AcPHNhHQPxAm9hVlHoZeJ_q9w> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAaIrcb1ffIOk3ecA9-3AcPHNhHQPxAm9hVlHoZeJ_q9w#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:11740;
    a Protein: .
  
  sub:_2 geneProductOf: hgnc:5472;
    a Protein: .
  
  sub:_3 rdf:object mesh:D017209;
    rdf:predicate belv:increases;
    rdf:subject sub:_2;
    a rdf:Statement .
  
  sub:_4 occursIn: species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:IGFBP3) -> bp(MESHPP:Apoptosis)", "p(HGNC:TF) -| (p(HGNC:IGFBP3) -> bp(MESHPP:Apoptosis))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "1.4" .
  
  sub:_5 dce:identifier "OMIM text for TF";
    dce:title "OMIM text for TF";
    dce:type "Online Resource" .
  
  sub:_6 prov:value "Human serum was fractionated over an IGFBP3 affinity column, and a 70-kD protein was eluted, sequenced, and identified (through database searching and Western immunoblot) as human TF. Biosensor interaction analysis confirmed that this interaction is specific and sensitive, with a high association rate similar to that of IGF1 (147440), and suggested that binding occurs in the vicinity of the IGFBP3 nuclear localization site. TF treatment blocked IGFBP3-induced cell proliferation in bladder smooth muscle cells and IGFBP3-induced apoptosis in prostate cancer cells.";
    prov:wasQuotedFrom sub:_5 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource sub:_5;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:44.412+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}