. . . . . . . . . . . . . . "TextLocation" . "Legend" . "a(CHEBI:dioxygen) -> deg(p(HGNC:HIF1A))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Hydroxylation at two proline residues on the HIF polypeptide mediates interactions\nbetween the b-domain of the von Hippel–Lindau protein (pVHL) and HIF [60]. Each\nsite can interact independently with pVHL, potentially contributing to the extremely\nrapid proteolysis of HIF-a that is observed under normoxic conditions. These\nsites contain a conserved LxxLAP motif and are targeted by proline hydroxylases\n(PHD) that, in mammalian cells, are provided by three isoforms termed PHD 1–3\n[61]." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.147+02:00"^^ . . .