. . . . . . . . . . . . . . . . . . . . "TextLocation" . "Review" . "gtp(p(PFH:\"RAS Family\")) => tloc(p(HGNC:BRAF),MESHCL:\"Intracellular Space\",MESHCL:\"Cell Membrane\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "The activation of B-Raf by Ras has been less well studied; however, the interacting\namino acids in the Ras-Raf interface are identical for B-Raf and C-Raf.129,130\n The association of Ras with B-Raf also translocates B-Raf to the cell membrane\nwhere it is activated.124 Interestingly, a membrane-free complex of B-Raf and\n14-3-3 can be activated in vitro by recombinant Ras. This is in stark contrast\nto A-Raf and C-Raf, which must undergo a series of phosphorylation reactions on\nserine and tyrosine residues in the cell membrane and cannot be activated by Ras\nalone.124,130 Of the Raf isoforms, B-Raf is activated first, and on stimulation\nby Ras, it heterodimerizes with C-Raf, the significance of which is not known.94" . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.485+02:00"^^ . . .