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statements drawn from 57 PubMeds. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#_8 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#_7 http://www.w3.org/ns/prov#value The activation of B-Raf by Ras has been less well studied; however, the interacting amino acids in the Ras-Raf interface are identical for B-Raf and C-Raf.129,130 The association of Ras with B-Raf also translocates B-Raf to the cell membrane where it is activated.124 Interestingly, a membrane-free complex of B-Raf and 14-3-3 can be activated in vitro by recombinant Ras. This is in stark contrast to A-Raf and C-Raf, which must undergo a series of phosphorylation reactions on serine and tyrosine residues in the cell membrane and cannot be activated by Ras alone.124,130 Of the Raf isoforms, B-Raf is activated first, and on stimulation by Ras, it heterodimerizes with C-Raf, the significance of which is not known.94 http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#_8 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#_7 http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI http://purl.org/dc/terms/created 2014-07-03T14:29:30.485+02:00 http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAbrnaUjLmz7Ta_X-wm3KQxDauQtyfNzzaZuE6LMgGJpI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234