. . . . . . . . . . . . . . . . . . . . . . "TextLocation" . "Legend" . "complex(p(HGNC:HIF1A),p(HGNC:CREBBP)) => tscript(p(HGNC:HIF1A))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "In a second hydroxylation-dependent control, b-hydroxylation of an asparaginyl residue\nin the C-terminal activation domain of HIF-a (N803 in human HIF-1a) is regulated\nby a HIF asparaginyl hydroxylase called FIH (factor inhibiting HIF) [62,63].\nHydroxylation at this site prevents the binding of the transcriptional co-activators\np300/CBP (CREB binding protein). Under normoxic conditions, these hydroxylation\nreactions provide a dual mechanism for HIF inactivation that involves proteolytic\ndestruction and the inhibition of transcriptional activity [64]." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.168+02:00"^^ . . .