sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_8 ; pav:version "1.4" . sub:_6dce:identifier "Entrez Gene summary: EP300" ; dce:title "Entrez Gene summary: EP300" ; dce:type "Online Resource" . sub:_7prov:value "Entrez Gene summary: Human: EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF." ; prov:wasQuotedFromsub:_6 . sub:_8rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcesub:_6 ; prov:wasDerivedFrombeldoc: , sub:_7 . }