. . . . . . . . . . . . . . . . . . "TextLocation" . "Review" . "cat(p(HGNC:EGLN3)) => p(HGNC:HIF1A,pmod(H,P,564))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Hydroxylation at two prolyl residues (Pro402 and Pro564 in human HIF-1α) mediates\ninteractions with the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex that\ntargets HIF-α for proteasomal destruction28, 29, 30, 34. Each site can interact\nindependently with VHL E3, potentially contributing to the extremely rapid proteolysis\nof HIF-α that is observed in oxygenated cells34. These sites contain a conserved\nLxxLAP motif and are targeted by a newly defined prolyl hydroxylase activity,\nthat in mammalian cells is provided by three isoforms termed PHD (prolyl hydroxylase\ndomain) 1-3 (refs. 31,32)." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:32.253+02:00"^^ . . .