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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdUQsV2HT1z9IVaXLCAtUfzY318x5XlsYdn8B6KfWrW4#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAdUQsV2HT1z9IVaXLCAtUfzY318x5XlsYdn8B6KfWrW4#_4 http://purl.org/dc/elements/1.1/identifier Gene Summary for ROCK1 http://www.tkuhn.ch/bel2nanopub/RAdUQsV2HT1z9IVaXLCAtUfzY318x5XlsYdn8B6KfWrW4#_4 http://purl.org/dc/elements/1.1/title Gene Summary for ROCK1 http://www.tkuhn.ch/bel2nanopub/RAdUQsV2HT1z9IVaXLCAtUfzY318x5XlsYdn8B6KfWrW4#_4 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RAdUQsV2HT1z9IVaXLCAtUfzY318x5XlsYdn8B6KfWrW4#_5 http://www.w3.org/ns/prov#value ROCK1 is a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. 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