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TextLocation
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Results
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p(HGNC:LRIG1) -| kin(p(HGNC:EGFR))
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Approximately 2000 hand curated statements drawn from 57 PubMeds.
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Copyright (c) 2011-2012, Selventa. All Rights Reserved.
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BEL Framework Small Corpus Document
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Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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To determine whether LRIG1 expression influences the ubiquitination and degradation
rate of ErbB receptors in the inducible expression system, we focused on the
effect of LRIG1 expression on the properties of EGFR in the PC3-LRIG1 cells. Similar
to the results with transfected 293T cells (Fig. 3), we observed that the induction
of LRIG1 expression markedly augmented the ubiquitination of EGFR in response
to EGF treatment (Fig. 5A). This potentiation of ligand-stimulated EGFR ubiquitination
correlated with a suppression of EGFR tyrosine phosphorylation and
receptor levels after growth factor treatment.
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support@belframework.org
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Selventa
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2014-07-03T14:29:34.147+02:00
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