sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "1.4" .
  sub:_6 dce:identifier "DUSP10 harvester omim" ;
    dce:title "DUSP10 harvester omim" ;
    dce:type "Online Resource" .
  sub:_7 prov:value "OMIM summary: Human: Dual-specificity phosphatases, such as DUSP10, negatively regulate the mitogen-activated protein kinase (MAPK) cascade by dephosphorylating both the threonine and tyrosine residues in TxY motifs in MAPKs ({1:Masuda et al., 2000}). Pubmed titles from omim summary: (summary is not available from this source) Entrez Gene GeneRifs summary: Human: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK." ;
    prov:wasQuotedFrom sub:_6 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource sub:_6 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}