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kin(p(HGNC:CDK4)) -| (p(HGNC:HRAS,sub(G,12,V)) -| bp(GOBP:"G1/S transition of mitotic cell cycle"))
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p(HGNC:HRAS,sub(G,12,V)) -| bp(GOBP:"G1/S transition of mitotic cell cycle")
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Approximately 2000 hand curated statements drawn from 57 PubMeds.
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BEL Framework Small Corpus Document
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Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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CDK4 is a cyclin-dependent kinase promoting G1 progression previously shown to be
posttranscriptionally down-regulated by Ras, a finding whose functional importance
has been confirmed because CDK4 can bypass Ras-induced growth arrest (31). CDK4
protein was also restored to near-normal levels by MKK7.
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