. . . . . . . . . . . . . . . . . . "TextLocation" . "Results" . "p(HGNC:IGF1) -> kin(complex(NCH:\"p85/p110 PI3Kinase Complex\"))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation\nof GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin\nand IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells,\nrespectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated\nby pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast,\nthe effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines\nwere not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig.\n2A), excluding the possibility that PKA induces GSK-3 phosphorylation through\nactivation of PI3K." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:34.673+02:00"^^ . . .