@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAje9g16xrK3t1eHQ-zf97Q5qGphTNDXb7eK1WmfzNaug> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAje9g16xrK3t1eHQ-zf97Q5qGphTNDXb7eK1WmfzNaug#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_3;
    a rdf:Statement .
  
  sub:_2 belv:variantOf sfam:MAPK%20Erk1%2F2%20Family;
    a proteinModification:, psimod:00696 .
  
  sub:_3 hasAgent: sub:_8;
    a go:0016301 .
  
  sub:_4 occursIn: mesh:D002462, species:9606;
    hasAnnotation: sub:_5;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject sub:_6;
    a rdf:Statement .
  
  sub:_5 dct:subject "TextLocation";
    rdf:value "Review" .
  
  sub:_6 hasAgent: sub:_7;
    a go:0005525 .
  
  sub:_7 geneProductOf: hgnc:9855;
    a Protein: .
  
  sub:_8 geneProductOf: hgnc:1097;
    a Protein: .
  
  sub:assertion rdfs:label "gtp(p(HGNC:RAP1A)) -> (kin(p(HGNC:BRAF)) -> p(SFAM:\"MAPK Erk1/2 Family\",pmod(P)))",
      "kin(p(HGNC:BRAF)) -> p(SFAM:\"MAPK Erk1/2 Family\",pmod(P))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_10;
    pav:version "20131211" .
  
  sub:_10 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:_9 prov:value """Additional support for the diverse functionality of Raf family members is provided
by the disparate responses of B-Raf and C-Raf to identical stimuli, as well as
the distinct messages that each isoform relays downstream to Rap1, which is a small
GTPase that functions as both an activator and repressor of Raf.115  Rap1-mediated
stimulation of B-Raf by cyclic adenosine monophosphate (cAMP) phosphorylates
ERK, whereas stimulation of C-Raf inhibits ERK phosphorylation.115""";
    prov:wasQuotedFrom pubmed:16170185 .
  
  sub:assertion prov:hadPrimarySource pubmed:16170185;
    prov:wasDerivedFrom beldoc:, sub:_9 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:31:15.580+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}