. . . . . . . . . . . . . . . "TextLocation" . "Review" . "kin(p(HGNC:PRKCZ)) -> bp(GO:\"establishment of cell polarity\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "In contrast to protein-binding inhibition, evidence has shown that pVHL binds to both\natypical PKC isoforms (l and z) through its b-domain, and in the case of activated\naPKCl, mediates its turnover as part of the E3-ligase function of pVHL [39,40].\nAlthough the functional significance of this inhibition remains elusive,\ngiven the central role for atypical PKCs (especially aPKCz) in establishing cell\npolarity in conjunction with PAR6 and the GTPase CDC42 [49], one could envisage\na scenario whereby the loss of pVHL leads to altered cell polarity and, by extension,\naberrant cell migration." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.321+02:00"^^ . . .