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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlPlSzEh-knHgXG4aJj8jKROr-9q23E7i0hLAEn7uNqQ#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAlPlSzEh-knHgXG4aJj8jKROr-9q23E7i0hLAEn7uNqQ#_6 http://purl.org/dc/elements/1.1/identifier PAK4 Hs ENTREZ Gene Summary http://www.tkuhn.ch/bel2nanopub/RAlPlSzEh-knHgXG4aJj8jKROr-9q23E7i0hLAEn7uNqQ#_6 http://purl.org/dc/elements/1.1/title PAK4 Hs ENTREZ Gene Summary http://www.tkuhn.ch/bel2nanopub/RAlPlSzEh-knHgXG4aJj8jKROr-9q23E7i0hLAEn7uNqQ#_6 http://purl.org/dc/elements/1.1/type Online Resource http://www.tkuhn.ch/bel2nanopub/RAlPlSzEh-knHgXG4aJj8jKROr-9q23E7i0hLAEn7uNqQ#_7 http://www.w3.org/ns/prov#value Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. 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