. . . . . "Paliperidone" . . . "Manic bipolar affective disorder" . . . . . . "Paliperidone is FDA-approved for schizophrenia aged 12-17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. An 8-week open-label study [9] examined paliperidone monotherapy for acute mania, mixed, or hypomanic episode in pediatric patients (n = 15, 6–17 years of age) with bipolar spectrum disorders. At the end of follow-up period, 11 subjects (73%) completed the study; treatment with paliperidone was associated with a 60% response rate (50% decrease in the Young Mania Rating Scale) and 40% remission (YMRS <12)" . . . . . . . "Children and adolescents (6-17 years)" . . . "RSA" . "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" . "MvwpmExq3ICFcY5B+BxMqvEkyn/L4WcUEGBvg9Ii25zQa3w/jFNhelcF/DdrqKosngpIawhpYivo17fgcaqod1wGoOgHleTBJ4T/LQeTcm6ctNvQDNGFmiht0AaftchduTGtIvRilMbSTy7pSCCxwMzXhtxU1YHX/12CM/5aQJ4=" . . "2022-09-16T11:50:40.267580"^^ . . . "2.3.0" .