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TextLocation
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Results
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act(p(HGNC:RIN1)) -> (kin(p(HGNC:EGFR)) -> bp(GOBP:"cell proliferation"))
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kin(p(HGNC:EGFR)) -> bp(GOBP:"cell proliferation")
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Approximately 2000 hand curated statements drawn from 57 PubMeds.
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Copyright (c) 2011-2012, Selventa. All Rights Reserved.
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BEL Framework Small Corpus Document
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Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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However, Rin1Δ expression did not complement Rin1 knockdown defects but instead caused
further inhibition of cell proliferation (Fig. 4E). These results suggest
that a functional Vps9 domain is critical for Rin1 activity in EGFR-mediated cell
proliferation. To verify that the Rin1 Vps9 domain was important for A549 cell
proliferation, Rin1Δ or wild type Rin1 expression constructs were transfected into
A549 cells and assayed for colony formation (Fig. 5, A and B). Only Rin1Δ expression
but not wild type Rin1 expression resulted in decreased cell proliferation.
These results indicated that Rin1 lacking a functional Vps9 domain acted as
a dominant negative, suggesting that the trafficking roles of Rin1 were mediating
EGFR proliferative signaling in A549 cells.
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support@belframework.org
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Selventa
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2014-07-03T14:31:17.507+02:00
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