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http://www.tkuhn.ch/bel2nanopub/RAoGwGW1WnchCs4TNqnM_jHJiGA4BI73rsKOvatVLEFd0#assertion http://www.w3.org/2000/01/rdf-schema#label act(p(HGNC:RIN1)) -> (kin(p(HGNC:EGFR)) -> bp(GOBP:"cell proliferation")) http://www.tkuhn.ch/bel2nanopub/RAoGwGW1WnchCs4TNqnM_jHJiGA4BI73rsKOvatVLEFd0#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:EGFR)) -> bp(GOBP:"cell proliferation") http://www.tkuhn.ch/bel2nanopub/RAoGwGW1WnchCs4TNqnM_jHJiGA4BI73rsKOvatVLEFd0#provenance http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 2000 hand curated statements drawn from 57 PubMeds. http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All Rights Reserved. http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAoGwGW1WnchCs4TNqnM_jHJiGA4BI73rsKOvatVLEFd0#_9 http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAoGwGW1WnchCs4TNqnM_jHJiGA4BI73rsKOvatVLEFd0#_8 http://www.w3.org/ns/prov#value However, Rin1Δ expression did not complement Rin1 knockdown defects but instead caused further inhibition of cell proliferation (Fig. 4E). These results suggest that a functional Vps9 domain is critical for Rin1 activity in EGFR-mediated cell proliferation. To verify that the Rin1 Vps9 domain was important for A549 cell proliferation, Rin1Δ or wild type Rin1 expression constructs were transfected into A549 cells and assayed for colony formation (Fig. 5, A and B). Only Rin1Δ expression but not wild type Rin1 expression resulted in decreased cell proliferation. 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