@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAoOA0W-OZYWHnTSARLnbgWXmGz0WRmOkNtvtIrU3LOrI> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAoOA0W-OZYWHnTSARLnbgWXmGz0WRmOkNtvtIrU3LOrI#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0005525 .
  
  sub:_2 geneProductOf: hgnc:5173;
    a Protein: .
  
  sub:_3 rdf:object mesh:D009369;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:_4 occursIn: species:9606;
    hasAnnotation: sub:_5;
    rdf:object sub:_3;
    rdf:predicate belv:decreases;
    rdf:subject schem:SP600125;
    a rdf:Statement .
  
  sub:_5 dct:subject "TextLocation";
    rdf:value "Results" .
  
  sub:assertion rdfs:label "a(SCHEM:SP600125) -| (gtp(p(HGNC:HRAS)) -> path(MESHD:Neoplasms))",
      "gtp(p(HGNC:HRAS)) -> path(MESHD:Neoplasms)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_7;
    pav:version "1.6" .
  
  sub:_6 prov:value """Ras-driven epidermal neoplasias generated on the surface of immunodeficient SCID mice
were treated topically with DMSO vehicle or SP600125 daily for 5 weeks. DMSO
and untreated control tissues displayed typical findings of neoplasia, including
invasion and disruption of the BMZ, as visualized by type VII collagen staining
(Fig. 2A). In contrast, tissues treated with SP600125 lacked invasive neoplasia
and retained sharp delineation of the BMZ, with a humanspecific desmoglein-3
antibody confirming the human origin of these tissues (Fig. 2A).""";
    prov:wasQuotedFrom pubmed:17440097 .
  
  sub:_7 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17440097;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:32.885+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}