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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAocOXAbAbXmujhQvbpspFIVH5tsYlsjKKxzaYJbAyhC4#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAocOXAbAbXmujhQvbpspFIVH5tsYlsjKKxzaYJbAyhC4#_5 http://purl.org/dc/elements/1.1/identifier Entrez Gene GeneRifs summary PRKAR1A Human http://www.tkuhn.ch/bel2nanopub/RAocOXAbAbXmujhQvbpspFIVH5tsYlsjKKxzaYJbAyhC4#_5 http://purl.org/dc/elements/1.1/title Entrez Gene GeneRifs summary PRKAR1A Human http://www.tkuhn.ch/bel2nanopub/RAocOXAbAbXmujhQvbpspFIVH5tsYlsjKKxzaYJbAyhC4#_5 http://purl.org/dc/elements/1.1/type Online Resource http://www.tkuhn.ch/bel2nanopub/RAocOXAbAbXmujhQvbpspFIVH5tsYlsjKKxzaYJbAyhC4#_6 http://www.w3.org/ns/prov#value Entrez Gene GeneRifs summary: Human: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Functional null mutations in this gene cause Carney complex (CNC), an autosomal dominant multiple neoplasia syndrome. This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. 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