@prefix this: <http://purl.org/np/RApfcWvESw2vh2LrKCzxRS9TxYrL1qYZeA16REZi-Wtx4> .
@prefix sub: <http://purl.org/np/RApfcWvESw2vh2LrKCzxRS9TxYrL1qYZeA16REZi-Wtx4#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix hp: <http://purl.obolibrary.org/obo/HP_> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubInfo;
    a np:Nanopublication .
}

sub:assertion {
  drugbank:DB00715 a biolink:Drug;
    rdfs:label "Paroxetine";
    biolink:category biolink:Drug .
  
  hp:0031217 a biolink:Disease;
    rdfs:label "hot flashes";
    biolink:category biolink:Disease .
  
  sub:association rdf:object hp:0031217;
    rdf:predicate biolink:treats;
    rdf:subject drugbank:DB00715;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    rdfs:label "Solid evidence justifies also uses of antidepressants for lessening hot flashes during menopause. This includes citalopram (Barton et al., 2010), escitalopram (LaCroix et al., 2012), paroxetine (Stearns et al., 2003) and desvenlafaxine";
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
    biolink:has_population_context sub:context;
    biolink:publications pmid:31622593;
    biolink:relation ncit:C94303 .
  
  sub:context a biolink:Cohort;
    rdfs:label "Adults";
    biolink:category biolink:Cohort;
    biolink:has_phenotype <http://purl.obolibrary.org/obo/GO_0042697> .
}

sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}

sub:pubInfo {
  sub:sig npx:hasAlgorithm "RSA";
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
    npx:hasSignature "gpK4npXn68O82cMmxUL+n5wotOW5Sc1dojJKQhhL+9rYlc7l7DzESxO3InijUtESl1DoOI00DYveFF9IhNg31IJVr22CqCxDcbQLlDVqAZm+JyOpM3pD9XQQggnvJOpT/FOxFpTfIa+b0t207GYYI4daihRNKXtrTcm+//acilo=";
    npx:hasSignatureTarget this: .
  
  this: prov:generatedAtTime "2022-09-16T11:48:47.437876"^^xsd:dateTime;
    prov:wasAttributedTo orcid:0000-0002-1501-1082;
    ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  
  biolink: pav:version "2.3.0" .
}