sub:provenance {
beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
dce:title "BEL Framework Small Corpus Document" ;
dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
pav:authoredBy sub:_4 ;
pav:version "1.6" .
sub:_3 prov:value """Cationic amphiphilic drugs such as amiodarone, perhexiline, diethylaminoethoxyhexestrol
(DEAEH) and tamoxifen can be first protonated in the intermembrane space
of mitochondria, and then electrophoretically transported into the mitochondrial
matrix thanks to the Δψm [3,4,40,42], as discussed in greater detail below. This
transfer across the inner mitochondrial membrane dissipates Δψm (Figure 1) and
increases the basal (state 4) mitochondrial respiration. This phenomenon, which
is called 'OXPHOS uncoupling', can also be observed in the case of some mitochondrial
poisons such as the protonophores 2,4-dinitrophenol (DNP) and carbonylcyanide
p-trifluoromethoxyphenylhydrazone (FCCP).""" ;
prov:wasQuotedFrom pubmed:18705745 .
sub:_4 rdfs:comment "support@belframework.org" ;
rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:18705745 ;
prov:wasDerivedFrom beldoc: ,
sub:_3 .
}