https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#Head https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://www.nanopub.org/nschema#hasAssertion https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#assertion https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://www.nanopub.org/nschema#hasProvenance https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#provenance https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://www.nanopub.org/nschema#hasPublicationInfo https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#pubinfo https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#assertion https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#BiologicalContext https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasBiologicalOrganizationLevel https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Tissue https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#BiologicalContext https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasOrganTerm serum https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Components https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasAction https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Decreased https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Components https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasObject thyroxine https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Components https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasProcess abnormal circulating thyroxine level https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#IncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasAOPName TPO Inhibition and Altered Neurodevelopment https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#IncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasAuthorStatus Open for citation & comment https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#IncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasOECDStatus WPHA/WNT Endorsed https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#IncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasPointOfContact Kevin Crofton https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#IncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasRoleInAOP KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasApplicabilityDomain Taxonomic: This KE is plausibly applicable across vertebrates and the overall evidence supporting taxonomic applicability is strong. THs are evolutionarily conserved molecules present in all vertebrate species (Hulbert, 2000; Yen, 2001). Moreover, their crucial role in zebrafish development, embryo-to-larval transition and larval-to-juvenile transition (Thienpont et al., 2011; Liu and Chan, 2002), and amphibian and lamprey metamorphoses is well established (Manzon and Youson, 1997; Yaoita and Brown, 1990; Furlow and Neff, 2006). Their role as environmental messenger via exogenous routes in echinoderms confirms the hypothesis that these molecules are widely distributed among the living organisms (Heyland and Hodin, 2004). However, the role of THs in the different species depends on the expression and function of specific proteins (e.g receptors or enzymes) under TH control and may vary across species and tissues. As such, extrapolation regarding TH action across species and developmental stages should be done with caution. https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasDescription All iodothyronines are derived from the modification of tyrosine molecules (Taurog, 2000). There are two biologically active thyroid hormones (THs) in serum, triiodothyronine (T3) and T4, and a few less active iodothyronines, reverse T3 (rT3), and 3,3'-Diiodothyronine (3,5-T2). T4 is the predominant TH in circulation, comprising approximately 80% of the TH excreted from the thyroid gland in mammals and is the pool from which the majority of T3 in serum is generated (Zoeller et al., 2007). As such, serum T4 changes usually precede changes in other serum THs. Decreased thyroxine (T4) in serum results from one or more MIEs upstream and is considered a key biomarker of altered TH homeostasis (DeVito et al., 1999). https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasID 281 https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasMeasurement&DetectionTechniques Serum T3 and T4 can be measured as free (unbound) or total (bound + unbound). Free hormone concentrations are clinically considered more direct indicators of T4 and T3 activities in the body, but in animal studies, total T3 and T4 are typically measured. Historically, the most widely used method in toxicology is the radioimmunoassay (RIA). The method is routinely used in rodent endocrine and toxicity studies. The ELISA method is commonly used as a human clinical test method. Analytical determination of iodothyronines (T3, T4, rT3, T2) and their conjugates, through methods employing HPLC, liquid chromatography, immuno luminescence, and mass spectrometry are less common, but are becoming increasingly available (Hornung et al., 2015; DeVito et al., 1999; Baret and Fert, 1989; Spencer, 2013; Samanidou V.F et al., 2000; Rathmann D. et al., 2015 ). In fish early life stages most evidence for the ontogeny of thyroid hormone synthesis comes from measurements of whole body thyroid hormone levels using LC-MS techniques (Hornung et al., 2015) which are increasingly used to accurately quantify whole body thyroid hormone levels as a proxy for serum thyroid hormone levels (Nelson et al., 2016; Stinckens et al., 2016; Stinckens et al., 2020). It is important to note that thyroid hormones concentrations can be influenced by a number of intrinsic and extrinsic factors (e.g., circadian rhythms, stress, food intake, housing, noise) (see for example, Döhler et al., 1979). https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasShortName T4 in serum, Decreased https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#KeyEvent https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasTitle Risk assessment for benefits analysis: framework for analysis of a thyroid-disrupting chemical https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#LifeStages https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasEvidence https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#High https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#LifeStages https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasLifeStage All life stages https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Overview https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasIncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#IncludedInAOP https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Overview https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasLifeStages https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#LifeStages https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Overview https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasSexApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#SexApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Overview https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasTaxonomicApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#TaxonomicApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#References https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasDOI 10.1080/15287390590912153 https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#References https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasTitle Risk assessment for benefits analysis: framework for analysis of a thyroid-disrupting chemical https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#SexApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasEvidence https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#High https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#SexApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasSex https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Male https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#TaxonomicApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasEvidence https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#Moderate https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#TaxonomicApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasScientificTerm Gallus gallus https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#TaxonomicApplicability https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI#hasTerm chicken https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#provenance https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#assertion http://www.w3.org/ns/prov#wasAttributedTo https://orcid.org/0000-0003-0593-2598 https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#pubinfo https://orcid.org/0000-0003-0593-2598 http://xmlns.com/foaf/0.1/name Saurav Kumar https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#sig http://purl.org/nanopub/x/hasAlgorithm RSA https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#sig http://purl.org/nanopub/x/hasPublicKey MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCPsaMrnmg/0bxwjIicrr5srkkyBt6XJZcWhj+IgMaoW3magRZPKpeQDu80wDXBfhL9u/xIVrgD2CwbUar4YoxoeZGhzhB9nlAiIgET7MWLDbatSCQB4KY+mDQ6AYOzgHkPTfJFf8TZllFC/XLMcx4gFryIfRGlBb/Fz+kUhWB3fQIDAQAB https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#sig http://purl.org/nanopub/x/hasSignature EDqUbW3DuG7zLdzjdfS4XE8zbOY5x9lNMEqURo3ClQXI90aNN5FVxd/6GoQB7OOInlgX1qNnEVktTSfLEEVSpZdaJy010YDMUsQKBi5BAsd6j0rgh+x3Iu3o6s4LecsdMdFUPD4YVJug6qPU7mc1HE6nLGcgEAql2RY81Vn6ifs= https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#sig http://purl.org/nanopub/x/hasSignatureTarget https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ#sig http://purl.org/nanopub/x/signedBy https://orcid.org/0000-0003-0593-2598 https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://purl.org/dc/terms/created 2024-08-01T12:10:35.430Z https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://purl.org/dc/terms/creator https://orcid.org/0000-0003-0593-2598 https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://purl.org/dc/terms/license https://creativecommons.org/licenses/by/4.0/ https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ http://purl.org/nanopub/x/wasCreatedAt https://nanodash.knowledgepixels.com/ https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ https://w3id.org/np/o/ntemplate/wasCreatedFromProvenanceTemplate http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ https://w3id.org/np/o/ntemplate/wasCreatedFromPubinfoTemplate http://purl.org/np/RAh1gm83JiG5M6kDxXhaYT1l49nCzyrckMvTzcPn-iv90 https://w3id.org/np/RArDtTbcusvumSkyIcI07_ljceWVGSlUQRjoRS5JnhSZQ https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate https://w3id.org/np/RALUzHtS1E_Mba_zwMhhENjZgd23vM0IivF-tUBC633dI