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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#_7 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#_6 http://www.w3.org/ns/prov#value To confirm that the coactivation of MEF2C by PGC-1α observed in reporter gene assays (Fig. 3B) was linked to direct binding of these two proteins, we tested whether PGC-1α directly interacts with MEF2C on this MEF-binding site. Increasing amounts of PGC-1α protein (amino acids 31–797) decreased the mobility of the complex containing MEF2C bound to the MEF-binding site, as visualized by a supershift in electrophoretic mobility-shift assays (Fig. 3D). As a control, PGC-1α protein that lacks the MEF2C-interaction domain (amino acids 1–180; see ref. 7) was not able to bind to MEF2C. Inclusion of an MEF2- specific antibody was able to supershift further the protein–DNA complex containing MEF2C, PGC-1α, and the MEF2-binding site (Fig. 3E). Neither a shift nor a supershift could be obtained when using the mutated ΔMEF site. These results indicate that MEF2s bind to the PGC-1α promoter and that PGC-1α coactivates MEF2 proteins on the PGC-1α promoter by a direct protein–protein interaction. http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12764228 http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#_7 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12764228 http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#_6 http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U#pubinfo http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U http://purl.org/dc/terms/created 2014-07-03T14:29:34.385+02:00 http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAriIQOzEcLQv04VcS6PeWOj7RxQq1kncvyKKLf6_lX1U http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234