@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix schem: <http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 geneProductOf: hgnc:4419 ;
    a Protein: .
  sub:_2 belv:translocationFrom go:0005622 ;
    belv:translocationOf schem:Luteinizing%20hormone%20%28human%29 ;
    belv:translocationTo go:0005576 .
  sub:_3 occursIn: species:9606 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(HGNC:GNRH1) -> sec(a(SCHEM:\"Luteinizing hormone (human)\"))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_4 dce:identifier "Chemical Society Reviews 1998 volume 27" ;
    dce:title "Chemical Society Reviews 1998 volume 27" ;
    dce:type "Other" .
  sub:_5 prov:value "A pure oestrogen receptor antagonist, ICI182780 11, was subsequently discovered and is now in late-stage clinical trial. 4.3 LHRH agonists Luteinizing hormone releasing hormone (LHRH) agonists form a third class of hormonal therapy for breast cancer, albeit only in pre-menopausal women. This limitation arises from their inhibitory effect on luteinizing hormone (LH) release from the pituitary (see Fig. 4) and consequent suppression of ovarian stimulation for oestrogen production. Whilst there are LHRH antagonists in clinical study, the ability of the agonists to mimic successfully the natural inhibitory feedback effect of oestrogen at the pituitary by inducing LHRH receptor downregulation provides a rare superiority over direct blockade. The agonists are all close analogues of LHRH 15, but their potency has had to be even greater than that of the natural decapeptide hormone itself to achieve the downregulating effect.15" ;
    prov:wasQuotedFrom sub:_4 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource sub:_4 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:29:43.595+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}